Key Publications

1.  Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF (1988) The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc Natl Acad Sci U S A 85: 5190-5194.

2. Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (1989) The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc Natl Acad Sci U S A 86: 3277-3281.

3. Rudd CE (1999) Adaptors and molecular scaffolds in immune cell signaling. Cell 96: 5-8.

4. Raab M, da Silva AJ, Findell PR, Rudd CE (1997) Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. Immunity 6: 155-164.

5. Prasad KV, Janssen O, Kapeller R, Raab M, Cantley LC, Rudd, CE (1993) Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. Proc Natl Acad Sci U S A 90: 7366-7370.

6. Telfer JC, Rudd CE (1991) A 32-kD GTP-binding protein associated with the CD4-p56lck and CD8-p56lck T cell receptor complexes. Science 254: 439-441.

7.  Rudd, C.E. Upstream-Downstream: CD28 co-signaling pathways and T-cell function (1996) Immunity 4, 527-534.  

8. da Silva, AJ, Li, Z., de Vera, C., Canto, E., Findell, P. and Rudd, CE (1997) Cloning of a novel T-Cell protein FYB Binds FYN and SH2-domain containing leukocyte protein 6 and modulates interleukin 2 production. Proc. Natl. Acad. Sci. USA 94, 7493-7498.

9. Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE (1998) FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. Proc Natl Acad Sci U S A 95: 8779-8784.

10.  Coyle, T. , Lehar, S., Lloyd, C., Tien, J., Delaney, T., et al., (2000) The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13, 88-105

11.  Raab, M, Pfister, S. and Rudd, C.E.(2001) CD28 Signaling via SLP-76/VAV Adaptors: Regulation of cytokine transcription independent of TcR ligation. Immunity, 15:921-33.  

12. Martin, M., Schneider, H., Azouz, A. and Rudd, C.E. (2001) CTLA-4 and CD28 directly modulate the surface expression of rafts in their modulation of T-cell function. J. Exp. Med 194:1675-81.

13.  Raab M, Wang H, Lu Y, Smith X, Wu Z, Strebhardt K, Ladbury JE, Rudd, CE (2010) T cell receptor "inside-out" pathway via signaling module SKAP1- RapL regulates T cell motility and interactions in lymph nodes. Immunity 32: 541-556.

14. Wang H, Moon EY, Azouz A, Wu X, Smith A, Schneider H, Hogg N, Rudd CE(2003) SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. Nat Immunol 4: 366-374.

15. Wang, H, McCann, F.E.Gordan, J.D., Wu, X., Raab, M., Malik, T., Davis, D.M. and Rudd,C.E. (2004) ADAP-SLP-76 binding differentially regulates supramolecular activation complex (SMAC) formation vs. conjugation. J. Exp. Med. 200, 1063-74.

16. Wang H, Liu H, Lu Y, Lovatt M, Wei B, Rudd CE (2007) Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol Cell Biol 27: 6863-6875.

17. Griffiths EK, Krawczyk C, Kong YY, Raab M, Hyduk SJ, Bouchard, D, Chan, VS, Kozieradzki I, Oliveira-Dos-Santos A J, Wakeham A, Ohashi, PS, Cybulsky MI, Rudd CE, Penninger, J. M. (2001) Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science 293: 2260- 2263.

18. Rudd CE, Schneider H (2003) Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol 3: 544-556.

19. Cai YC, Cefai D, Schneider H, Raab M, Nabavi N, Rudd CE (1995) Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation. Immunity 3: 417-426.

20. Coyle AJ, Lehar S, Lloyd C, Tian J, Delaney T, Manning S, Nguyen T, Burwell T, Schneider, H, Gonzalo JA, Gosselin M, Owen LR, Rudd, CE, Gutierrez- Ramos J. C. (2000) The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13: 95-105.

21. Raab M, Pfister S, Rudd CE (2001) CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation. Immunity 15: 921-933.

22. Smith X, Schneider H, Kohler K, Liu H, Lu Y, Rudd CE (2013) The chemokine CXCL12 generates costimulatory signals in T cells to enhance phosphorylation and clustering of the adaptor protein SLP-76. Science Signaling 6: ra65.

23.  Valk E, Leung R, Kang H, Kaneko K, Rudd CE, Schneider H (2006) T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor. Immunity 25: 807-821.

24.  Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, Wei B., Hogg N, Garside P, Rudd, CE (2006)  Reversal of the TCR stop signal by CTLA-4. Science 313: 1972-1975.

25.  Rudd CE. Cell cycle 'check points' T cell anergy. (2006) Nat Immunol. 7, 1130-2. PMID: 17053794.

26.  Rudd CE (2008) The reverse stop-signal model for CTLA4 function. Nat Rev Immunol 8: 153-160.

27.  Pillars Article: Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF. (2010) Pillars article: the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. 1988.J Immunol. 185, 2645-9.

28. Lu Y, Schneider H, Rudd CE (2012) Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal. Blood 120: 4560-4570.

29  Wei, B., Han, L., Abbink, T. E., Groppelli, E., Lim, D., Thaker, Y. R., Gao, W., Zhai, R., Wang, J., Lever, A., Jolly, C., Wang, H., and Rudd, C. E. (2013) Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. Retrovirology 10, 101.

30.  Camirand, G., Wang, Y., Lu, Y., Wan, Y.Y., Lin, Y. et al., (2014) CD45 ligation increases antigen-mediated expansion of regulatory T cells by promoting interactions with dendritic cells in vivo. J Clin Invest. 124, 4603-13

31.  Huang, Y. H., Zhu, C., Kondo, Y., Anderson, A. C., Gandhi, A., Russell, A. et al. (2015) CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature 517, 386-390.

32.   Liu, H., Schneider, H., Recino, A., Richardson, C., Goldberg, M. W. and Rudd, C. E. (2015) The immune adaptor SLP-76 binds to SUMO-RANGAP1 at nuclear pore complex filaments to regulate nuclear import of transcription factors in T-cells . Molecular Cell 59, 840-849.

33.  Taylor, A., Harker, J. A., Chanthong, K., Stevenson, P. G., Zuniga, E. I. and Rudd, C. E. (2016) Glycogen synthase kinase 3 inactivation drives T-bet-mediated downregulation of co-receptor PD-1 to enhance CD8(+) cytolytic T cell responses. Immunity 44, 274-286.

34.  Taylor A, D, Rothstein D and Rudd, C.E. (2018) Small molecule inhibition of PD-1 transcription is an effective alternative to antibody blockade in cancer therapy. Cancer Research 78, 706-717.

35.   Krueger J and Rudd C.E. (2017) Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells. Immunity 46, :529-531.

36.  Taylor, A. and Rudd, C.E. (2017) Glycogen Synthase Kinase 3 Inactivation compensates for the lack of CD28 in the priming of CD8+ Cytotoxic T-cells: Implications for anti-PD-1 Immunotherapy. Front. Immunol., 8:1653

37.   Raab, M. Lu Y, K Smith X, Kohler, K., Smith, X., Strebhardt K, Rudd C.E. (2017) Nat Commun LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation. Nat. Commun. 8.16001.

38. Thaker YR, Raab M, Strebhardt K and Rudd CE. (2019) GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity. Nat Commun.10(1):4804. 

39.  Rudd, C.E, and Taylor, A. (2020) GSK-3 inhibition down-regulates inhibitory co- receptor LAG-3 on CD4 and CD8+ T-cells for enhanced anti-tumor immunity. Cell Reports 30(7):2075-2082.

40.  Krueger, J., Santinon F., Kazanova, A., Issa, M, Larrivee, B., Milhalcioiu, C. and Rudd, C.E. (2020) Hydroxychloroquine (HCQ) reverses anti-PD-1 immune murine checkpoint blockade: TCF1 as a marker in humans for COVID-19 and HCQ therapy. medRxiv preprint doi: